Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication

Kodakarensis Dna Replication Machinery

Title of Document: THERMOCOCCUS KODAKARENSIS DNA REPLICATION MACHINERY Miao Pan, Ph.D., 2012 Directed By: Professor Zvi Kelman, Institute for Bioscience and Biotechnology Research DNA replication is the basis for the propagation and evolution of living organisms. It requires the combined efforts of numerous proteins. DNA replication in archaea has been shown to be more similar to eukarya than b...

Human mitochondrial DNA replication machinery and disease.

The human mitochondrial genome is replicated by DNA polymerase γ in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respiration ultimately induces mitochondrial genetic diseases, including mtDNA depletion syndromes (MDS...

Human parvovirus B19: a mechanistic overview of infection and DNA replication.

Human parvovirus B19 (B19V) is a human pathogen that belongs to genus Erythroparvovirus of the Parvoviridae family, which is composed of a group of small DNA viruses with a linear single-stranded DNA genome. B19V mainly infects human erythroid progenitor cells and causes mild to severe hematological disorders in patients. However, recent clinical studies indicate that B19V also infects noneryth...

Building up the machinery for DNA replication.

Cellular and viral control of the initiation of DNA replication.

Cell-free replication of SV40 DNA in extracts prepared from S phase cells is at least 20-fold more efficient than in extracts from G1 cells. The increased activity of S phase extracts correlates with the presence of an S phase-specific cellular factor that enhances DNA unwinding at the replication origin. This change in origin-DNA structure during the initiation of SV40 replication proceeds thr...